Facts and interesting facts about CBD from the world of science!
What does the endogenous cannabinoid system mean?
The endocannabinoid system (ECS) is a biological concept based on the discovery of receptors that are modulated by the plant compound tetrahydrocannabinol. After that, a whole family of endogenous (endogenous) ligands (endocannabinoids) was discovered.
Cannabidiol enhances anandamide signaling…
ZNS
Memories, memory, learning: Particularly high density of CB1 (cannabinoid receptor-1) in the prefrontal cortex, hippocampus, dentate gyrus… Expression on ependymal cells and neuroglia cells indicates a regulatory effect on neurogenesis and gliogenesis. CB1 expression on myelinating Schwann cells supports the theory that the endocannabinoid system affects nerve fiber myelination.
More information can be found here:
Spatial distribution of cannabinoid receptor type 1 (CB1) in the normal canine central and peripheral nervous system
EPILEPSY
CBD restores excitability and morphological impairments, thereby normalizing neural network function to pre-epilepsy levels.
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Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.
MULTIPLE SCLEROSIS
The endocannabinoid system and its therapeutic utility in multiple sclerosis: ideas for other neuroinflammatory diseases.
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The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases
IBD/IBD
CBD is relatively weakly effective. The inhibition of inflammation comes from the also non-psychoactive THCA and this is recommended for clinical use
More information can be found here:
Anti-Inflammatory Activity in Colon Models Is Derived from Δ9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts.
ASTHMA
CBD reduces airway inflammation and fibrosis in allergic asthma
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Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma.
BREAST CANCER
CBD has an apoptotic effect (kills up to 30% of tumor cells)
CBDA prevents tumor cells from migrating (metastasis)
More information can be found here:
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
